Read the Latest Cisco 4000 Model Comparison

The Cisco ISR 4000 platform is modular and upgradable, so you can add new services without changing equipment. It supports multiple application-aware services concurrently while maintaining WAN performance of up to 2 Gbps, even during heavy traffic loads. The backplane architecture supports high-bandwidth, module-to-module communication at speeds up to 10 Gbps.

The 4000 Series includes Cisco Trust Anchor Technologies that help mitigate modern cyberattacks by verifying platform integrity and providing protection from counterfeit and unauthorized modification 

of hardware and software.

The 4000 Series contains five platforms: the 4451, 4431, 4351, 4331, 4321 and 4221 ISRs.

Benefits-Cisco ISR 4000 Series

In the following table you can see the main Cisco ISR 4000 model comparison: ISR 4221 vs. 4321 vs. 4331 vs. 4351 vs. 4431 vs. ISR 4451.

Feature	4221	4321	4331	4351	4431	4451
Form factor	1 RU Desktop	1 RU Desktop	1 RU	2 RU	1 RU	2 RU
Integrated WAN ports	GE / SFP	GE / SFP	GE / SFP	2 PoE GE / SFP	2 PoE GE / SFP	2 PoE GE / SFP
	1 GE	GE	GE	GE/ SFP	2 GE / SFP	2 GE / SFP
			SFP
Performance	35Mbps	50 Mbps	100 Mbps	200 Mbps	500 Mbps	Gbps
	Upgradable to 75 Mbps	Upgradable to 100 Mbps	Upgradable to 300 Mbps	Upgradable to 400 Mbps	Upgradeable to 1 Gbps	Upgradable to 2 Gbps
Management port		1 GE (Integrated Out of Band)
Network Interface Modules (NIM)	2	2	2	3	3	3
Enhanced Services Module (SM-X)	N/A	N/A	single-wide	2 single- or1 double-wide	N/A	2 single- or double-wide
Integrated Services Card (ISC) slots	N/A	1	1	1	1	1
		(PVDM 4)	(PVDM 4)	(PVDM 4)	(PVDM 4)	(PVDM 4)
USB ports (type A)	1	1	1	2	2	2
Default/max Flash	8 GB	4 GB / 8 GB	4 GB / 16 GB	4 GB / 16 GB	8 GB / 32 GB	8 GB / 32 GB
Default/max DRAM	4 GB	4 GB / 8 GB	4 GB / 16 GB	4 GB / 16 GB	4 GB / 16 GB	4 GB / 16 GB
Power supply type	External: AC	External: AC, PoE	Internal: AC, PoE	Internal: AC, PoE or DC	Internal: AC, PoE or DC	Internal: AC, PoE or DC
Redundant power supply	No	No	No	No	Yes	Yes
					Internal RPS	Internal RPS
Module online insertion and removal (OIR)	No	Yes	Yes	Yes	Yes	Yes
Server virtualization platform (UCS E-Series) and Network Compute Engine (NCE)	N/A		2-core single-wide, 2-core NCE	2 core single-wide, 2-core NCE		2-core single-wide, 2-core NCE
		4-core NCE	4-core single-wide, 4-core NCE	4 core single-wide, 4-core NCE	4-core NCE	4-core single-wide, 4-core NCE
				4 core double-wide,		4-core double-wide,
				6 core double-wide,		6-core double-wide,
				8 core double-wide		8-core double-wide
Advanced Security	4221	4321	4331	4351	4431	4451
Zone-based firewall and NAT services	VRF-Aware Firewall and Network Address Translation (NAT)
Hardware VPN acceleration(DES, 3DES, AES)	No
IPSEC VPN services	FlexVPN, Easy VPN remote server, Enhanced Easy VPN, Dynamic Multipoint VPN (DMVPN),
	Group Encrypted Transport VPN (GET VPN), V3PN, MPLS VPN
SSL VPN	No
Intrusion prevention	Yes (Snort for Singnature Based and FirePower as nGIPS)
Anomaly Detection and Machine Learning	Cisco Self Learning Networks (SLN)
Network foundation protection	ACL, FPM, control plan protection, control plane policing (CoPP), QoS, role-based CLI access, source-based RTBH, uRPF, SSHv2
Cisco Umbrella Branch Support	Yes
Cisco Cloud Web Security	Yes
Identity-based networking	No	No	No	No	No	No
Cisco TrustSec	Security Group Tag Exchange Protocol (SXP), SGT over GETVPN
	SGT over IPSEC
	SGT over DMVPN
	SGT-based ZBFW
	Port/Layer 3 interface/IP/subnet-to-SGT mapping
	SGT export in Flexible NetFlow
Unified Communications	4221	4321	4331	4351	4431	4451
Local conferencing	N/A	Yes	Yes	Yes	Yes	Yes
Digital signal processor support	N/A	PVDM4	PVDM4	PVDM4	PVDM4	PVDM4
Cisco Unified Survivable Remote Site	N/A	Up to 50	Up to 100	Up to 750	Up to 1200	Up to 2000
Telephony support
Cisco Unified Communications	N/A	Up to 50	Up to 100	Up to 250	Up to 350	Up to 450
Manager Express support
Cisco Unity Express	N/A	Use Cisco Unity Connection on UCSE	Use Cisco Unity Connection on UCSE	Use Cisco Unity Connection on UCSE	Use Cisco Unity Connection on UCSE	Use Cisco Unity Connection on UCSE
(NM, SM, or ISM)
Cisco Unified Border Element (CUBE)	N/A	100	400	1000	3000	6000
(SIP/H.323 sessions)
nano Cisco Unified Border Element (nanoCUBE)	N/A	N/A	N/A	N/A	N/A	N/A
(sessions)
Digital voice and video (T1/E1 channels)	N/A	Up to 240	Up to 360	Up to 720	Up to 720	Up to 1200
Analog/BRI voice	N/A	Up to 8 ports (FXS, FXO, E/M, BRi)	Up to 12 ports (FXS, FXO, E/M, BRi)	Up to 20 ports (FXS, FXO, E/M, BRi)	Up to 12 ports (FXS, FXO, E/M, BRi)	Up to 20 ports (FXS, FXO, E/M, BRi)
Routing and Multicast	4221	4321	4331	4351	4431	4451
IPv4 routing protocols	RIP v1/v2, EIGRP, OSPF, BGP, PBR, PfR	RIP v1/v2, EIGRP, OSPF, BGP, PBR, PfR	RIP v1/v2, EIGRP, OSPF, BGP, PBR, PfR	RIP v1/v2, EIGRP, OSPF, BGP, PBR, PfR	RIP v1/v2, EIGRP, OSPF, BGP, PBR, PfR	RIP v1/v2, EIGRP, OSPF, BGP, PBR, PfR
Multicast routing protocols	PIM-SM, mroute (static route), and MLD	PIM-SM, mroute (static route), and MLD	PIM-SM, mroute (static route), and MLD	PIM-SM, mroute (static route), and MLD	PIM-SM, mroute (static route), and MLD	PIM-SM, mroute (static route), and MLD
IPv6 routing protocols	EIGRP, RIP, OSPFv3, IS-IS,	EIGRP, RIP, OSPFv3, IS-IS,	EIGRP, RIP, OSPFv3, IS-IS,	EIGRP, RIP, OSPFv3, IS-IS,	EIGRP, RIP, OSPFv3, IS-IS,	EIGRP, RIP, OSPFv3, IS-IS,
	BGP and PBR	BGP and PBR	BGP and PBR	BGP and PBR	BGP and PBR	BGP and PBR
Wireless LAN	4221	4321	4331	4351	4431	4451
Integrated 802.11 b/g/n access point	N/A	N/A	N/A	N/A	N/A	N/A
Integrated 802.11 a/b/g/n access point	N/A	N/A	N/A	N/A	N/A	N/A
Unified and autonomous mode	N/A	N/A	N/A	N/A	N/A	N/A
RP-TNC connectors for field-replaceable	N/A	N/A	N/A	N/A	N/A	N/A
optional high-gain antennas
Diversity (dual antennas)	N/A	N/A	N/A	N/A	N/A	N/A
Wireless LAN controller module	N/A	Available on UCS E-Series	Available on UCS E-Series	Available on UCS E-Series	Available on UCS E-Series	Available on UCS E-Series
Wireless WAN	4221	4321	4331	4351	4431	4451
3G /4G LTE cellular	Yes
Cat 6 LTE Advanced	Yes†
GPS Support	Yes
Indoor Antenna	Yes (Various antenna using 2 x TNC connectors supporting MIMO)
Outdoor antennas	N/A	N/A	N/A	N/A	N/A	N/A
Integrated Switching	4221	4321	4331	4351	4431	4451
Maximum switched Ethernet ports	2 x 8	16	40	72	24	72
Maximum switched Ethernet LAN ports with PoE	0	16	40	72	24	72
PoE support (wattage)	N/A	120 W	250 W	500 W	250 W	500 W
without PoE boost					(with optional power supply redundancy)
PoE support (wattage)	N/A	260 W	500 W	950 W	530 W	990 W
with PoE boost			(no power supply redundancy)
EtherSwitch Service Module type (width)	N/A	N/A	single	2 single or 1 double	N/A	2 single or 1 double
Application Services		4321	4331	4351	4431	4451
Intelligent Path Control	PfR	PfR	PfR	PfR	PfR	PfR
Network Contention Control	QoS, HQoS	QoS, HQoS	QoS, HQoS	QoS, HQoS	QoS, HQoS	QoS, HQoS
Application Visibility	NBAR v2	NBAR v2	NBAR v2	NBAR v2	NBAR v2	NBAR v2
WAN Optimization	N/A	ISR-WAAS	ISR-WAAS,	ISR-WAAS,	ISR-WAAS	ISR-WAAS,
			vWAAS on UCS E-Series	vWAAS on UCS E-Series		vWAAS on UCS E-Series
Akamai Connect	N/A	Yes	Yes	Yes	Yes	Yes
Cisco Application Centric Infrastructure	Application Policy Infrastructure Controller (APIC) with Enterprise Module

† With CAT6 LTE Advanced theoretical DL speed of 300 Mbps, with 2 NIM slots ISR4221 and ISR4321, customer may need the performance license to maximize CAT6 LTE Advanced theoretical full potential capability with 2 NIM CAT6 LTE Advanced slots depending on specific carrier SP provisioning capability & capacity.

Read the original updated info of Cisco 4000 Series. http://www.cisco.com/c/en/us/products/collateral/routers/4000-series-integrated-services-routers-isr/datasheet-c78-732542.html#_ftn7

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